UC San Diego researchers have been working for years to build trust with communities of unhoused people who use drugs in both San Diego and Tijuana. However, since spring, some 10% of their research participants have tested positive for syphilis. This development has raised concerns about the ongoing study's ability to continue due to a drug shortage that is affecting their treatment protocols. The researchers are also facing challenges related to federal constraints, which may limit their access to resources needed to conduct the study effectively. Despite these obstacles, they remain committed to their research and aim to find solutions to ensure the safety of their participants while maintaining their commitment to public health initiatives. [1] [2]